While promoting "Oceans 13" in Cannes with co-star Matt Damon, the two started to rip on Brangelina, saying "Brad has had it tough" between being "hobbled with children" and "that horrible, ugly wife." Clooney went on to say that Brad should just kill himself to get out of the horrendous situation.
Of course, Pitt also stars in the upcoming caper, and the gang has a history of ragging on each other and playing practical jokes -- TMZ's favorite? Clooney allegedly putting a "Small Penis on Board" bumper sticker on Pitt's car. That's what friends are for.