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Chuck Lorre -- Blasting Charlie With Monkey Jokes?

4/29/2011 12:05 PM PDT BY TMZ STAFF

Chuck Lorre is taking a vicious shot at an actor -- accusing him of being a drug addict who is "impossible to work with" ... but the shocker is he's NOT talking about Charlie Sheen. Maybe.

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At the end of last night's "The Big Bang Theory" ... Lorre's vanity card seems to be joking about a monkey that was on the episode -- saying its "behavior became increasingly erratic, to the point of refusing to come out of his trailer to rehearse."

The card continues, "The monkey is a heroin addict. Yes, hard as it may be to believe, the monkey had a monkey on his back." It goes on to say the monkey is in detox and a 12 step program.

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But after Lorre's announcement he's retooling "Two and a Half Men" without Charlie -- and Charlie's nuclear response, we gotta ask ...





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