Michelle Obama -- Oprah's Neighbors Pissed Over FLOTUS' Hawaii Vacation

Michelle Obama's visit to Oprah's Hawaii compound has crippled the neighborhood around O's home ... and some neighbors are pissed.

Some of the residents and business people around Oprah's palatial 12-bedroom Maui estate -- where Michelle recently retreated to spend the last few days of her 40s -- are all telling the same story ... Michelle's visit is making day-to-day life almost impossible.

The owner of nearby Goble's Flower Farm tells us ... security checkpoints have been set up on the roads ... blocking customers from shopping there.

Other business owners complain they can't stock their shelves because road closures have screwed up their deliveries.

A worker at Grandma's Maui Coffee tells us, employees are arriving VERY late to work.

And fun is also affected. Recreational areas (like hiking trails) have also been shut down.

Not good for Oprah's relations with her neighbors, which have already been strained from her generally imposing presence. But it's nothing that a good cocktail party can't solve.