Neil Patrick Harris: Good Genes or Good Docs?

Neil Patrick Harris' good looks are center stage!

Here's the then 16-year-old "Doogie Howser, M.D." doctor at a Los Angeles holiday party back in 1989 (left) and 25 years later -- the now 41-year-old Broadway badass leaving a New York City theater late last month (right).

What's up doc?