Jerry Seinfeld -- Derek Jeter Made a Mistake ... He Shouldn't Have Played in Boston

Apparently Derek Jeter CAN do wrong in the eyes of Yankees fans ... so says Jerry Seinfeld who tells TMZ Sports ... #2 should NOT have played his final game in Boston!!!

It's a pretty big issue in the Yanks community -- a lot of New Yorkers believe Jeter should've hung up his cleats after his last game at Yankees Stadium last week ... and NOT played out the final games of the season at Fenway against the Red Sox.

Clearly, Seinfeld thinks Jeter chose poorly ... saying, "He should NOT have played in Boston. You don't owe anybody ANYTHING!"

Of course, Jeter got a standing ovation in Beantown ... with the crowd chanting his name ... but according to Jerry, the storybook ending went on a few pages too long.