George Lopez to Trump F*** That Whore

7/19/2015 7:12 AM PDT

George Lopez to Donald Trump -- F*** That Whore

George Lopez went on a full-scale attack in Arizona Saturday night, getting the audience to send a very loud message to Donald Trump ... "F*** that Puto."

Lopez was clearly angered over Trump's comments about Mexicans, and the crowd roared with approval.

It's interesting ... "Puto" is Spanish for male prostitute, and it's considered homophobic by some.

It didn't matter ... George, whom NBC is considering as a replacement for Trump on "Celebrity Apprentice," wanted to send the loudest message he could.