Is the Sexiest Man Alive going to party with Brit? Don't worry ... he won't.

George Clooney, party pal of Danny DeVito, was spotted leaving his midtown hotel in NYC last night, when photogs asked if he'd be partying with Britney when he returned to Los Angeles.

Clooney's response: "I guess not, huh." The gray-haired hunk joked about his late night carousing with DeVito, saying, "Apparently, he can't drink with me, that's the problem."

We're disappointed. Gorgeous George would have been a vast improvement over Paris.