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Good Neighbors: Oprah Hits the Road with Ellen

2/22/2007 1:02 PM PST BY TMZ STAFF

Click to return to TMZ.comEllen hit the road with her neighbor, Oprah Winfrey, and gave O a set of keys to her house ... including the liquor cabinet!

The Big O stopped by "The Ellen DeGeneres Show," just a week before Ellen hosts the Oscars, and Oprah's Oscar night special airs. The talk show queens both live in the same Santa Barbara area ... imagine the block party!

In the episode airing today, the two also go on a mock road trip -- making fun of Oprah's cross-country trip with BFF Gayle King -- with Ellen and Oprah breaking out into a rousing rendition of "I Will Survive."

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