Is Lindsay Dumping Movie and Career with Hard Partying?

Did Lindsay Lohan throw away the chance to work with screen legend Shirley MacLaine after her weekend bust on suspicion of DUI? Is she quickly becoming the female equivalent of the former Robert Downey, Jr., i.e., an instant liability on film sets because of her crazy antics?

TMZ is told that "Poor Things" -- a crime caper about a granny gang starring MacLaine and Olympia Dukakis -- is set to begin shooting with Lohan on Thursday, with three weeks of location filming in Los Angeles. Lohan's court date on the DUI charge isn't until August, so that won't matter, but if she's checking into rehab, as has been reported, she clearly won't be around to work.

So far, the film's production company, Still Rolling Productions, tells the trades that the shoot won't be affected. No studio is yet attached, and calls to Lohan's people and MacLaine's reps haven't been returned.

But the bigger question is whether the drinking and drug problems are killing Lohan's career, making her uninsurable for films that studios and investors pour millions of dollars into -- because she's proven to be so erratic. One source tells TMZ that Lohan should be an absolute angel on the "Poor Things" shoot if she doesn't want to further jeopardize her career, and a film insurance executive tells TMZ that he would have to think "very, very hard" before insuring Lohan because she's become such "a loose cannon."