Oprah Should Run for President in 2020

Oprah Winfrey's stirring speech at the Golden Globes may have been a precursor for a presidential run in 2020 ... at least that's the hope of some famous folks who watched and listened -- and her longtime companion says she's in.

O's best bud, Gayle King, is clearly down for it, with an asterisk. Ditto Christian Slater, Laurence Fishburne, Andy Samberg, Geoff Stults and Eric McCormack.

Stedman went way further and said O would "absolutely do it" and now it's up to the people.

Oprah has made it clear in the past ... she has no interest in politics, but people change.