Rosanna Arquette -- Good Genes or Good Docs?

2/13/2011 9:00 AM PST BY Johnny Lopez
Rosanna Arquette knows good work when she sees it.

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Here's the 26-year-old actress/director/producer back in 1986 (left) -- and 25 years later, the 51-year-old version at an event in L.A. this week (right).

Desperately seeking ... her secret.