Madonna -- I Don't Support Drug Use ... and I Never Have!

Madonna says DeadMau5 is DeadWrong ... claiming she was NOT promoting drug use at a concert in Florida ... despite allegations she used her stage time to glamorize the drug ecstasy.

Deadmau5 -- one of the most famous DJs in the world -- had attacked Madonna​ as a "f**king idiot" for asking the crowd at the Ultra Music Festival if anyone has "seen Molly" -- Molly is a slang term for the active ingredient in ecstasy (video below ... warning: it contains explicit language).

Now, Madge is lashing back ... with a pair of mouse ears.

The Material Girl posted a photo of herself in Mickey Mouse gear ... with the caption, "From one mouse to another I dont support drug use and i never have. I was referring to the song called "Have You Seen Molly" written by my friend Cedric Gervais who I almost worked with on my album."

Deadmau5 saw the tweet and replied ... saying, "Fair enough, I was just voicing my concerns as I usually do. +1 respect for clearing it up personally ... regardless, just be a little more aware of what you should represent at EDM events, and I'll watch my mouth."

Madge replied ... "Communication is always best. You should have called me first, we could have cleared it up 'privately.' ;) See you on the road."