'Who Framed Roger Rabbit?' Star Bob Hoskins -- I'm RETIRING from Acting ... I Have Parkinson's

British acting legend Bob Hoskins -- who played P.I. Eddie Valiant in "Who Framed Roger Rabbit?" and Smee in "Hook" -- just announced ... he's retiring from acting after being diagnosed with Parkinson's disease.

The 69-year-old actor issued a statement earlier today, claiming he was diagnosed last fall. Hoskins also thanked his fans for their support, saying he had a "wonderful career."

No kidding -- his career spanned roughly 80 movies ... and his work in the British films "The Long Good Friday" and "Mona Lisa" earned him a Cannes Award, a Golden Globe for Best Actor, several BAFTA Awards, and an Academy Award nomination.

Then again ... Hoskins also starred in the 1993 live action "Super Mario Bros."

Nobody's perfect.