George Clooney said arrivederci to freedom with the boys Friday night in Italy ... the day before he ties the knot with Amal Alamuddin.
Clooney and Amal starred at a rehearsal dinner with family and friends in Venice ... and it looks like they went on separate journeys afterward with their respective genders.
Clooney hit up a restaurant with all the other dudes -- it's unclear where Amal went.
Most of George's famous friends are also in Venice for the wedding ... including Bono, Bill Murray, Matt Damon and Ellen Barkin.
Now it's only a matter of time.