'Grey's Anatomy' Star Jesse Williams and Wife Divorce

Jesse Williams is headed for splitsville -- he and his wife, Aryn Drake-Lee, are divorcing ... TMZ has learned.

Sources close to the couple tell us the "Grey's Anatomy" star and wife of almost 5 years filed for divorce last week ... it's unclear who filed, but we're told the split is amicable.

They have 2 young kids together -- son, Maceo and daughter, Sadie.