Walking out to more applause than usual, David Letterman opened tonight's "Late Show" by taking three shots at himself in less than a minute!
Among the zingers, Dave told the audience, "I got into the car this morning and the navigation lady wasn't speaking to me."
Things take a more serious turn later in the monologue -- where Dave reportedly apologizes to his wife for his affairs. CBS is keeping that part under wraps until tonight.
Letterman Monologue -- Burned in 60 Seconds
10/5/2009 7:20 PM PDT BY TMZ STAFF
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