Walking out to more applause than usual, David Letterman opened tonight's "Late Show" by taking three shots at himself in less than a minute!
Among the zingers, Dave told the audience, "I got into the car this morning and the navigation lady wasn't speaking to me."
Things take a more serious turn later in the monologue -- where Dave reportedly apologizes to his wife for his affairs. CBS is keeping that part under wraps until tonight.
Waiting for your permission to load the comments.