Regis Philbin tried to tame a mighty Vespa on the streets of NYC this afternoon ... and lost.
The 80-year-old was riding the wild scooter for a bit with David Letterman ... when Regis tipped his bike and spilled onto the asphalt.
Philbin grimaced as he hit the ground -- but being the tough son of a bitch that he is, Reeg got right back up and finished the bit.
A rep for "Regis and Kelly" tells TMZ, Regis didn't suffer any injuries during the minor spill, and is doing just fine.
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