Rob Lowe -- Does Jay Z Represent Actors?!

The Dez Bryant contract negotiation was HUUUGE for Jay Z -- 'cause after he scored the WR a fat new $70 MILLION deal ... Rob Lowe had one question -- "Does Jay Z represent actors?!"

First off, Lowe was outspoken about the whole Bryant contract standoff with the Cowboys -- tweeting earlier this week, "Pay Dez. #Cowboys #NFL This is a no-brainier."

So, when we broke the news to him last night at Craig's in West Hollywood -- the guy was PUMPED for #88.