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Arquette/Harper-- Weird Coincidence

10/11/2010 7:07 PM PDT BY TMZ STAFF

Best friends do everything together ... and in the case of the Arquettes and the Harpers -- they even call off their marriages around the same time.

1011_david_ben_laura_courteney_getty_table

Back before the two power couples each called it quits -- the foursome spent a whole lotta time together throughout the years ... because Laura, Ben, Courteney and David were all best friends.

So David and Courteney separate several months back -- and suddenly Ben pulls the plug on his marriage.  Coincidence? 

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