Patty Duke Dead at 69

3/29/2016 9:33 AM PDT BY TMZ STAFF
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0329_patty_duke_remembering_launchHollywood legend Patty Duke -- who won an Oscar for playing Helen Keller in "The Miracle Worker" -- has died. 

She was 69. 

Duke passed away at 1:20 AM Tuesday morning. She died from sepsis due to a ruptured intestine. 

Duke's son, Sean Astin, said the family is "relieved" because Duke was in a lot of pain and the process took a long time to play out. 

Duke's family issued a statement, saying, "This morning, our beloved wife, mother, matriarch and the exquisite artist, humanitarian, and champion for mental health, Anna Patty Duke Pearce, closed her eyes, quieted her pain and ascended to a beautiful place." 

"We celebrate the infinite love and compassion she shared through her work and throughout her life."

Duke was a child star -- winning the Oscar for Best Supporting Actress at 16 years old in 1963. 

She was married 4 times ... including to actor John Astin -- the father of "Lord of the Rings" star Sean Astin.

Duke is survived by her husband, Michael Pearce, and her 3 kids.