Cheryl "Salt" James and Sandra "Pepa" Denton desperately need your help, and they're offering a big reward.
Salt was barely holding back tears as she told us about losing her Oprah 25th anniversary bag in NYC, minutes before our photog spotted them.
There was incredibly valuable stuff inside the bag, including -- shockingly -- her wedding ring.
A finder's fee awaits anyone who finds it ... hit her up on Twitter @DaOnlySalt.
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