Rev. Run's daughter Angela Simmons is about to really make it BIG -- her new Harlem Globetrotters anniversary uniforms are debuting at Fashion Week, and TMZ Sports got a first look.

Our spies backstage in NYC spotted Angela's hard work on the backs of a few players -- Thunder Law, Smooth Staples, and Cheese Chisholm -- as they prepped for the catwalk Tuesday evening.

Angela's design will make its debut on the hardwood during the Globetrotters' upcoming season -- the 90th for the legends.

Angela tells us her goal with the new look was to honor the team's history. Translation: lots of red, white, blue ... and stars. 

Fashion Week bonus for the 'trotters? 2 words -- SUPERMODEL ACCESS.