O was walking out of CBS in NYC on Wednesday morning when our photog told her about T.I.'s comment ... and you really have to see the look on her face. She's flat-out dumbfounded.
But she bounces back quickly, and in true Oprah fashion. Interesting response, since many people think she could be prez if she ran. Anyway, pay attention, T.I. ... this one's for you.
Bonus: Oprah explains why she did NOT watch the Democratic debate. Blame it on Lupita!