CSI Creator's Wife: Our Marriage is DOA

4/28/2011 3:30 PM PDT

'CSI' Creators Wife Files for Divorce

The wife of the creator of "CSI" has filed for divorce ... TMZ has learned.

Jennifer Zuiker -- whose hubby, Anthony Zuiker, created the crime show which has generated more than $6 billion --  filed legal docs in L.A. County Superior Court, citing "irreconcilable differences."

Jennifer is asking for child and spousal support.

And, we're told, there is NO PRENUP.  So divide $6 billion by 2!

The couple married in April, 1999.  They have 3 boys.