Fredric Brandt -- Famed Botox Doc to the Stars ... Dead

8:40 AM PT -- Law enforcement sources tell us Brandt's death was a suicide. There are reports he killed himself by hanging, but our sources would not confirm that.

Dr. Fredric Brandt ... the dermatologist who smoothed out the skin of dozens of stars including Madonna, Stephanie Seymour and was the inspiration for Martin Short's character on Tina Fey's new show, was found dead over the weekend.

The Dade-County Medical Examiner confirms to TMZ -- the 65-year-old Botox pioneer -- was found in his Coral Gables home.

Dr. Brandt was the go-to person for the aging rich and famous, especially in NYC. The New York Times wrote his patient's skin "is smooth and yet not freakishly taut."

Dr. Brandt has a huge business selling high-end dermatology products called "Dr. Brandt."

Martin Short's character on Fey's "Unbreakable Kimmy Schmidt" which airs on Netflix mimics Brandt's look, and he's quite eccentric.

There are reports Brandt was extremely depressed over Short's seeming portrayal of him.