Jesse Jane has a message for all the haters who still think she was drunk when she passed out in Vegas ... take a date rape drug and see what happens to you.

TMZ posted video of the porn star Tuesday in a stupor on the Vegas Strip.    

Jesse is extremely upset by Internet users, whose comments include:

- "Tequila is no bueno, that's what u call white girl wasted."

- "It's hard to hold your liquor when you have no soul."

- "Just leave her on her back, that when she's most comfortable."

Jesse's now hurling back at all the trash talkers.