Prince Harry Speaks, Big Acts Perform at Vax Live Concert in L.A.

Nothing says things are getting back to normal in the U.S. like a packed concert in Los Angeles ... where Prince Harry helped drive home the point of the night: ending the worldwide pandemic.

The visual is a little jarring at first -- thousands of people, all fully vaccinated, gathered Sunday night at SoFi Stadium for Global Citizen’s "Vax LIVE: The Concert to Reunite the World" charity show. The Duke of Sussex got a huge ovation as he delivered an impassioned speech about everyone working together in this "defining moment" to end wipe out COVID-19.

Harry and Meghan Markle are serving as campaign chairs for Vax Live, and teamed up with some huge musical acts to put on the free charity concert for 47,000. Some of the performers included Foo Fighters, Eddie Vedder, J Balvin, H.E.R. and Jennifer Lopez ... who was joined on stage by her fully-vaxxed mom for a loving embrace.

Harry, making his first appearance back in America since Prince Philip's funeral in England -- told the crowd, "Tonight is a celebration of each of you here, the vaccinated frontline workers in the audience and the millions of frontline heroes around the world."

President Biden also addressed the audience -- via recorded message -- and other special guest speakers included Ben Affleck, Chrissy Teigen, Jimmy Kimmel, Sean Penn and David Letterman.