They continued ... "She was surrounded by her closest family and fought with great strength, leaving us with a certainty of her never-ending joy of living and whatever adventures lie ahead. As iconic as she was on screen, she was an even more amazing mother and grandmother. We are grateful to the incredible team of doctors and nurses at the Moffitt Cancer Center for their care."
Her two children wrote in the statement, "Our mother's zest and passion for life, her children, grandchildren and her many animals, not to mention her eternal joy of creating, were unparalleled and leave us inspired to live life to the fullest just as she did."
Alley became a household name as Rebecca Howe on "Cheers" from 1987-1993 … a role that netted her both an Emmy and Golden Globe in 1991. She went on to snag her second Emmy for her role in "David's Mother."
Fans will also remember her for her leading role in the 80s flick "Look Who's Talking," the films "Star Trek II: The Wrath of Khan," "It Takes Two" and many others.
She's survived by her two kids, William True and Lillie Price.