George Lopez' Wife Files For Divorce

George Lopez' wife has filed for divorce ... TMZ has learned.

TMZ first reported the couple's intention to call it quits.  Now Ann Lopez has filed legal docs to make it official.

According to the divorce petition, filed today in L.A. County Superior Court by disso-queen Laura Wasser, Ann cites "irreconcilable differences."

Ann is asking for spousal support and primary physical custody of their 14-year-old daughter.

We're told there is no prenup.

The couple has been married for 17 years.