Dr. Ernesto Torres, director of the Centro Medico trauma center in Puerto Rico, said Camacho went into cardiac arrest early Saturday. He was then taken off life support and died shortly thereafter.
Camacho and a childhood friend were shot several times Tuesday night while sitting inside their car. Camacho was hospitalized following the attack, but went into cardiac arrest a short time later. He died Saturday. Camacho's friend died at the scene.
Officials in Puerto Rico have launched an investigation into the shooting -- but so far, no suspects have been identified ... and no arrests have been made.
During his professional career, Camacho was a helluva boxer -- with a record of 79-5-3.
Sporting his trademark front-curl, Camacho battled with legends like Felix Trinidad, Julio Cesar Chavez and Sugar Ray Leonard. In fact, Camacho famously knocked out Leonard in 1997.
Outside the ring, Camacho was no stranger to trouble ... having been arrested several times. In fact, he was sent to prison for burglarizing a computer store in 2005. During the arrest, cops say they found the drug ecstasy.
Camacho's wife had also filed two domestic abuse complaints against the boxer over the years. And last year, Macho was arrested for allegedly abusing his teenage son.
An investigation into the shooting is ongoing.
Camacho was 50 yearsold.