Vice President's Son Beau Biden Dies of Brain Cancer at 46

5/31/2015 4:18 AM PDT

Vice President's Son Joseph 'Beau' Biden Dead ... Dies at 46

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Beau Biden, the son of Vice President Joe Biden, died Saturday night of brain cancer.  He was 46. 

The younger Biden has suffered repeated tragedy in his life.  When he was 3, his mother and sister were killed in a car crash and he was badly injured.  His dad was sworn into the United States Senate at his bedside.

In 1987 Beau suffered a life-threatening aneurysm.  In 2010 he had a stroke.  He was diagnosed with brain cancer 2 years ago.

Beau had been an accomplished politician -- twice serving as Attorney General of Delaware -- and there was talk he'd become governor.

He was married with 2 kids.