Tucson SWAT Conducting Raid in Nancy Guthrie Case

11:00 AM PT -- The Pima County Sheriff's Office tells TMZ ... a federal court-ordered search warrant was executed at a residence near E. Orange Grove Rd. and N. First Ave. Friday night, which was connectde to the Guthrie case.No arrests were made.

There was also a traffic stop conducted, and a person was questioned. Again, no arrests resulted.

11:53 PM PT -- Fox News has reported that at least three people have been detained in connection with the investigation into the disappearance of Nancy Guthrie, according to a local law enforcement source.

The Pima County Sheriff’s Department confirmed the activity at the neighboring residence is connected to the Guthrie investigation ... however, they’re keeping details under lock and key due to the joint nature of the investigation and a request from the FBI to stay tight-lipped.

Cops also clarified online speculation saying ... "Reporting that current law enforcement activity is surrounding a home belonging to a former county attorney is NOT accurate."

It looks like the biggest break yet in the Nancy Guthrie kidnapping ... Pima County deputies are swarming a home in the Tucson area, and apparently, taking multiple people into custody.

The Sheriff's Department's SWAT unit rolled out Friday night in the rain with a huge show of force ... first reported by NewsNation's Brian Entin, whose crew got the video of cops walking out with a man and woman.

The home is about 2 miles from Nancy's home, and the Sheriff's Dept. came ready for anything -- there are reportedly about 2 dozen officers on the scene ... including FBI agents.

Entin says it appears the 2 people taken out of the house are a mother and son.

It's unclear if the 2 people are suspects or persons of interest ... or if they've been arrested -- but law enforcement has a search warrant related to the Guthrie case, according to Entin.

A judge apparently issued a search warrant and law enforcement is currently inside the house. NewsNation reports this was all set in motion after cops made a traffic stop of a white van, and the driver has also been detained.

Entin says there was no confrontation at the house ... doors were not broken down. He says the 2 people appeared to surrender voluntarily.