Blake Griffin to Caitlyn Jenner, 'Thanks for Giving Your Daughters Daddy Issues'

"On behalf of the entire NBA and half of the rappers on the Billboard charts, I want to thank you for giving your daughters their daddy issues!"

That's NBA superstar Blake Griffin giving it to Caitlyn Jenner at the Comedy Central "Roast of Alec Baldwin" -- proving absolutely nothing is off limits ... and it's all hilarious!

Blake and Caitlyn were on the dais for the show (which airs Sept. 15) -- and it's customary for roasters to go after each other in addition to burning the guest of honor.

What's interesting about this situation ... Blake famously dated Caitlyn's daughter, Kendall Jenner, beginning back in 2017 -- so it's not like the NBA star was going after a stranger.

Comedy Central only released a snippet of Blake's set -- but so far, so good.

Here's another joke ...

"Caitlyn completed her gender reassignment in 2017 ... finally confirming that no one in that family wants a white d*ck."