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Big break in the Matthew Perry death investigation -- there have been multiple arrests made, including at least one doctor ... TMZ has learned.

Law enforcement sources tell us ... multiple law enforcement agencies have executed search warrants and seized computers, phones and other electronic equipment to determine who supplied Perry with the ketamine that caused him to lose consciousness last October and drown in his hot tub in Pacific Palisades, Los Angeles.

Perry had been getting ketamine infusion therapy for anxiety and depression, but the last therapy was a week and a half before his death, so the ketamine in his system was not doctor-prescribed.

Gena Rowlands, who famously played Allie in "The Notebook," is dead ... TMZ has learned.

The retired actress died Wednesday afternoon at her home in Indian Wells, CA ... where she was surrounded by family, including her husband, Robert, and her daughter Alexandra Cassavetes.

We're told her son, director Nick Cassavetes, had also been at the home frequently this week.

The upcoming Britney Spears biopic has a chance to be extra authentic ... as the new owner of the singer's childhood home is inviting Universal Pictures to film on location.

The current homeowner of the old Spears family home in Kentwood, Louisiana tells TMZ … she's totally open to camera crews descending on the property to shoot scenes for the Britney flick.

It sounds like the owner's willing to bend over backward to make this happen ... she tells us she's cool with the production company removing her furniture and bringing in their own set pieces, which would need to happen to accurately recreate Britney's 1980s and '90s childhood environment.

Alyvia Alyn Lind is getting a pretty good cut of some streaming dough for an upcoming Netflix production ... she's set to earn more than $500,000 for the limited series.

The 17-year-old actress is starring in "Wayward" ... and her minor's contract shows just how handsomely she's being paid.

According to the contract, filed in court and obtained by TMZ, Alyvia is raking in $75,000 per episode for the inaugural season.

Michael Chandler's Christmas wish is to put his fist through Conor McGregor's face on the UFC's December card -- and while Santa Claus can't help here -- Dana White can, and Iron Mike desperately hopes he books the long-awaited fight as UFC 310's main event!

TMZ Sports talked to 38-year-old Chandler on Wednesday ... and asked the #6 ranked lightweight for his reaction to White recently declaring McGregor (and therefore Michael) would NOT be fighting in 2024.

"If [Conor and I] can fight in December, let's do it. I'm in. But the fact of the matter is I've stayed ready since I left training camp for that June 29 fight and I am staying ready to take a fight. Any fight, if this fight doesn't look like it's happening in December," Chandler told us.

"Love Island: USA" star Nicole Jacky is resurfacing amid some major drama with her partner from the show, Kendall Washington ... but he's not with her.

Nicole showed up to Chelsea Studios in New York City for Wednesday's reunion show taping ... and instead of rolling in with Kendall, she was with castmates Kaylor Martin and Liv Walker.

Thing is ... Nicole has been super quiet since the show ended, when Kendall had some old nudes leaked online.

A piece of horror movie history could be yours ... as the famed haunted house from "Poltergeist" has officially hit the market.

The home -- which served as the central location in the Steven Spielberg-scripted supernatural flick -- hasn't been listed for sale in more than 45 years ... but is now looking for new living owners.

The abode, located outside Los Angeles in Simi Valley, CA, boasts a 16,000-square-foot lot, with 4 bedrooms, 2.5 bathrooms, a large swimming pool and a jacuzzi.

Justin Baldoni and Blake Lively's cast and crew agree there's conflict between the "It Ends With Us" costars -- but we've learned he's not the clear-cut villain, as some people who worked on the film are standing with Justin.

Production sources tell TMZ ... JB, who directed and co-starred in the romantic drama, is actually viewed quite favorably by a lot of the crew, as he was generally a nice guy to work with and cared a lot about the production.

Despite reports the cast and crew are rallying around Blake in the feud with Justin over creative differences ... we're told that's an overstatement.

A firearm registered to notorious cop killer Christopher Dorner was recovered during the arrest of two men suspected in the armed robbery of a $1 million watch ... and the crazy thing is Dorner's been dead for over a decade.

Prosecutors in Los Angeles say Beverly Hills Police officers discovered a handgun registered to Dorner during a Saturday morning search of the suspects' Airbnb.

The firearm is a Glock 21 .45 caliber handgun ... and prosecutors say it was loaded and tucked inside a pillowcase when cops found it during their search. Authorities also released photos allegedly showing one of the suspects holding the gun.

Ángel Salazar -- famous for playing Al Pacino's trusted sidekick "Chi Chi" in "Scarface" -- was filming an indie spin-off of the iconic gangster movie when he died ... and we've got the first look at him in action.

Director Eric Spade Rivas tells TMZ … Ángel seemed fatigued when shooting scenes in New Jersey back in April, but he was still getting ready to film more scenes later this year in Miami.

The movie is called "The Brooklyn Premiere" ... and it also features Steven Bauer, who plays Manny Ribera in the OG "Scarface." The film's about a Brooklyn film director facing a midlife crisis who sets out to make a "Scarface" parody comedy to revive his career.

Dominique Dawes says the drama surrounding Jordan Chiles' bronze medal is "unfortunate" ... but she tells TMZ Sports she's sure the saga will show off the gymnast's true championship mettle.

The Olympic legend, of course, knows a thing or two about what Chiles is experiencing ... as she was once part of a similar ordeal a couple decades ago.

You might recall ... at the 2000 Games in Sydney, she and USA gymnastics placed fourth in the team competition -- but some 10 years later, the Americans were named rightful winners of the bronze medal after officials declared Team China had an underage competitor.

Kehlani claims her ex is abusive -- physically, emotionally and verbally -- high all the time ... and his alleged behavior is having a negative effect on their daughter, Adeya Nomi.

Kehlani got court-ordered protection from Javaughn Young-White, Adeya's father, after claiming he smashed through her locked bedroom door back in June ... according to new legal docs obtained by TMZ.

The singer claims her ex flew into a fit of anger after she questioned him about a notice she received in the mail indicating he'd applied for public assistance.

Brandon Thomas Lee won't be getting a mulligan at his fancy country club ... we've learned Tommy Lee's son has been given the boot for bad behavior.

Sources with direct knowledge tell TMZ ... Pamela Anderson's firstborn had his membership at the Sherwood Country Club in Thousand Oaks, CA revoked ... after getting into a shouting match with a fellow member on the golf course.

We're told the reality star was on the links a few weeks back when trouble erupted on the 13th hole. Our sources say BTL was driving too close to the green when a member who lives on the course spotted him.

Rachel Lindsay has some sage advice for the new "Bachelor" lead Grant Ellis -- while you're on the show looking for love ... look for a lawyer, too!

The former "Bachelorette" lead tells TMZ the most important thing Grant can do is protect himself if he proposes on the ABC show. RL speaks from experience ... as she's now knee-deep in a bitter divorce with Bryan Abasolo, who she met on the show back in 2017.

Rachel's romance with Bryan has spiraled into a courtroom nightmare after their 2019 wedding -- the chiropractor is now getting $13,000 a month in spousal support from her ... and he's pushing for even more cash!

1:20 PM PT -- Pras saved the song's outro bits for his IG stories ... apparently, Lauryn Hill values serving clickbait and buying Gucci bags over keeping her word.

Pras has nothing but time now that The Fugees' anniversary tour is no longer happening, and TMZ Hip Hop obtained his newest track -- ripping Lauryn Hill and addressing his federal case.

On the track "Bar Mitzfa," Pras incorporates a rock 'n roll-rap hybrid to air his frustrations when he raps, "Don't blame me, blame her, she made the mess ... not another f***ing penny, is what I told [Wyclef Jean]."

We're told the song was recorded sometime last week, when Pras needed to blow off steam ... on the heels of low ticket sales shutting down the legendary hip hop trio's reunion plans.

Jaden Smith appears to be done with GF Sab Zada, because he's on a yacht overseas with a smoking hot IG model ... and things are looking passionate between them.

Will Smith's son is in Ibiza right now with an influencer named Khleopatre ... and Jaden's all over her, grabbing her booty and sucking face -- in the water, on the deck, pretty much everywhere.

Jaden and Khleopatre certainly don't look like this is a first date -- they seem very comfortable with each other, smiling, laughing and having a great time. If it is a first date ... it's the best one ever!