Twista entered a not guilty plea in his marijuana possession case, and his legal team is looking into the possibility the rapper was profiled the night he got busted.
Twista was in the Porter County courthouse on Monday to face the misdemeanor charge. As we reported ... he and 3 other members of his crew got busted last month when cops pulled him over before his Valparaiso concert ... and found half an ounce of weed.
But Twista's attorney, Lakeisha Murdaugh with the Scott King Group, says the Rolls-Royce Phantom Twista was in might have tipped off cops the headliner was inside -- and she suspects the traffic stop was not random.
Murdaugh tells us she wants to review all police transmissions from that night to see what caught cops' attention.