Peyton Manning got himself a job this NFL season after all ... ROASTER ... and his target will be Rob Lowe.
The ex-QB will be on the dais during the "Comedy Central Roast" of Peyton's fellow DirecTV pitchman -- which airs on Labor Day.
David Spade will serve as Roast Master -- and will get some help from his old "Tommy Boy" co-star Bo Derek.
Everyone knows people on the dais are just as big of targets as the guests ... so, good luck Peyton's forehead -- it's gonna be a long night.
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