Playing alongside Ray Lewis, Rod Woodson and Adalius Thomas, Siragusa -- nicknamed "Goose" -- helped the Ravens defense set the record for fewest points allowed in a regular season on their way to winning a title.
In his 12 years in the league, he compiled 22 sacks and 564 combined tackles.
Following his playing career, Siragusa gained national fame for his role as an NFL sideline reporter and analyst for Fox. He made audiences laugh with his unique style and knowledge of the game.
Siragusa had also hosted several TV shows after retiring from the NFL, including "Man Caves."
Colts owner Jim Irsay just tweeted about Siragusa's death, saying, "The Goose, Tony Siragusa has passed away at 55.. I’m heart broken as is all of Colts Nation."
Ravens owner Steve Bisciotti also commented on Siragusa's passing, writing in a statement, "Our deepest prayers and sympathies go out to Kathy, their three children and the rest of the Siragusa family."
"This is a tremendously sad day for the Baltimore Ravens. We appreciate everyone who has expressed an outpouring of support for our players, coaches and staff."