Call it the rematch ... Michael Lohan and Kate Major had another blowout fight tonight -- but this one ended with her in handcuffs for DUI ... TMZ has learned.
Michael claims they were in a nasty argument at their home in FL when she hit him multiple times in the face.
We're told Lohan called 911, and just as cops arrived ... Kate was fleeing in her car.
She didn't get far -- according to law enforcement, Kate crashed into some bushes near the house ... and was busted for allegedly driving intoxicated.
We're told she's still in custody, and getting booked for DUI ... and possibly domestic battery.
Less than a month ago Kate locked herself in a bedroom, and claimed Michael was trying to break down the door while brandishing a knife.
Police responded to calm the sitch, but no one was arrested ... that time.