Shane Mosley Warns Dana White that De La Hoya Would Destroy Him in Boxing Match

Shane Mosley has some friendly advice for Dana White -- DON'T ACCEPT OSCAR DE LA HOYA'S BOXING CHALLENGE ... fight him in the Octagon instead!

Remember, Oscar and Dana have been beefing hard lately -- with Dana calling Oscar all sorts of nasty names on ESPN.

So, Oscar issued a challenge of his own -- going on SiriusXM's 'Luke Thomas Show' and saying, "Let's get in the ring. Three rounds. Let's do this."

De La Hoya also told TMZ Sports that he would beat Dana's ass if things actually came to blows.

And, since "Sugar" Shane Mosley knows exactly what it's like to fight the Golden Boy -- he beat Oscar twice -- we asked if he had any advice for the UFC boss.

"Don't take the challenge," Mosley joked at the Smash Global MMA party in L.A. ... "I wouldn't do that. That wouldn't be a smart move."

Mosley's fiancee suggested the boxer give Dana some 1-on-1 personal training ... but Mosely replied, "It's not gonna help."

But, get this, Shane DOES think the guys should fight -- but he wants MMA rules since Oscar would have too big of an advantage in a boxing match.

BTW -- Mosley also reminded us that he and Oscar BOTH fought Shaquille O'Neal back in the day ... and we found the video.

And, it's AMAZING!!!