He was referring to Pence's ridiculous defiance when he went to the Mayo Clinic this week, ignoring protocol as he was the only one in the room not wearing a mask. He says he was tested, but that really doesn't make a difference. They told him to wear one and he didn't.
The artist who painted the Pence pic -- Lushsux -- has a history with 50. He's turned him into Donald Trump ... something that clearly doesn't sit well with the rapper/mogul.
And, what really set 50 off ... when Lushsux turned him into Taylor Swift. He said at the time ... "Man look at this s***, TF is wrong with this guy he won't stop ... Swifty cent, I'd like to hit this MF right in the back of his head while he doing this s***.'