Hayden Panettiere, or someone close to her, was treated with meds typically used for overdose victims ... TMZ has learned.
We've confirmed, through sources in Greenville, SC, that Narcan was found in the apartment where she died. Narcan is administered nasally to reverse the effects of an opioid overdose, and we're told the device used to dispense it was found on a mattress.
We know first responders on the scene mentioned an "overdose" and CPR efforts while reporting back to dispatch.
However, we also know 2 ambulances rushed to the apartment, which seems to point to 2 people in distress in the apartment ... so, it's unclear who received the dose of Narcan.
Hayden Panettiere's autopsy showed no signs of trauma ... according to the Greenville County Coroner's Office.
The coroner released some details from the autopsy in a press release Monday, saying ... "no signs of trauma were discovered that would have contributed to the death. The cause and manner of death remain pending further investigation and the completion of additional studies."
The rest of the release reiterates information we've already reported ... first responders arrived at a residence in Greenville, South Carolina, after receiving a call about a woman in cardiac arrest Sunday.
Hayden Panettiere mourners continue to flood social media, honoring the late actress ... and her "Scream" co-star Emma Roberts is offering an emotional goodbye.
Hayden and Emma starred together in "Scream 4" ... and Emma's tribute post reads, "Rest in peace, my sweet friend. You are so loved, and you will be forever missed ❤️."
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Emma included two snaps of them together from back in the day.
As we told you ... Hayden was found dead inside a South Carolina residence on Sunday ... and an emergency call was made for an "unresponsive female" in "cardiac arrest." The dispatch audio mentioned a possible overdose, and her autopsy showed no signs of trauma.
Hayden Panettiere was found dead by a friend inside a South Carolina home ... and Emergency Medical Service workers responded to a call about a person in "cardiac arrest" and an "unresponsive female," TMZ has learned.
Law enforcement sources tell us ... Hayden's friend called 911 at 1:51 PM Sunday to report that the actress was unresponsive and in cardiac arrest inside the residence in Greenville, SC.
TMZ obtained the dispatch audio of responders sending medics to her location to perform CPR on someone who overdosed, which you can hear above. Page Six was first to report.
It's unclear if Hayden's on-again, off-again boyfriend Brian Hickerson placed the call.
We're told Greenville police officers and EMS workers quickly responded, and paramedics attempted to resuscitate Hayden using "advanced cardiac life support." Our sources say this treatment builds on CPR by adding special medicines, breathing tubes, and heart rhythm tracking.
Two ambulances raced to Hayden Panettiere's death scene and rolled out stretchers, which seems to confirm what we've been hearing ... that Hayden wasn't the only one in the apartment unit.
Law enforcement sources tell TMZ ... the 2 ambulances were dispatched to the scene, although no one was wheeled out of the apartment and the ambulances left without a patient inside.
A source tells us, Hayden's on-and-off-again boyfriend, Brian Hickerson, was living in the unit with his brother. Hayden and Brian flew from L.A. to South Carolina Saturday and were both at the apartment.
Hayden Panettiere's colleague Alyson Stoner broke down in tears after learning of her death ... sharing a video on social media paying tribute to her fellow "Kingdom Hearts" star.
Alyson was very emotional in the short clip she posted Monday ... telling fans she knows she looks rough at the moment -- but asking for them to give her grace as she talks about her late friend.
Hayden Panettiere spoke lovingly about her daughter in one of her final interviews ... hoping her child would someday understand their many years apart.
The actress opened up to parenting magazine Momé in July -- just weeks before her death -- recalling the traumatic birth of her now-11-year-old daughter, Kaya, and the painful custody decision that followed.
Hayden said she nearly died when she gave birth to Kaya in December 2014 ... she needed seven blood transfusions and three hours of surgery.
Hayden told the photog she was dealing with some pinched nerves in her lower back ... and she promised she was on the mend before slowly stepping into her waiting SUV.
This clip falls right in line with what we've heard from sources ... one of whom told us she'd been complaining of back pain regularly over the past year.
Hayden Panettiere's on-again, off-again boyfriendBrian Hickerson told us she was the textbook "Sunday girl" when we last talked to him ... and three months later she was found dead on a Sunday in an apartment linked to him.
Brian sat down with TMZ's Charlie Neff back in May -- Hayden had a new memoir out at the time -- and it's interesting to look back at the conversation in the wake of Hayden's sudden death.
Hayden and Brian started dating in 2018, and he held their relationship in high regard ... telling us Hayden "is the sweetest thing in the world."
Brian put it like this ... "It's not about who you spend Saturday night with, it's about who you spend all Sunday with, and Hayden Panettiere is a Sunday girl."
Hayden Panettiere's final Instagram post was a 15-year-old memory ... and the man beside her in the throwback snap tells TMZ he was surprised to see it resurface.
Director and photographerRandall Slavin is the man in the photo, and he tells TMZ ... the black-and-white pic was not recent -- it was taken about 15 years ago at a party inside a friend's home.
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He says he recently stumbled across the image on an old hard drive and texted it to Hayden ... but had no idea she planned to share it publicly and was surprised when it was posted on her page on July 27.
Amid Hayden Panettiere's suspected drug overdose death, the fire department and coroner's office raced to the scene -- and TMZ obtained photos of the emergency response.
In one photo, you can see a fire truck parked and multiple ambulances outside the Greenville, South Carolina residence where Hayden took her last breaths.
In another pic, you can see the Greenville County coroner's truck stopped in front of the same building.
Law enforcement sources told TMZ ... Hayden's body was found Sunday inside an apartment by a friend, who then called 911 to report that the actress was unresponsive and in cardiac arrest.
Hayden Panettiere was looking forward to a fresh start just three months before her death ... saying she felt she had "a lot more life to live."
Hayden made the heartbreaking comment on Jay Shetty's "On Purpose" podcast in May ... telling him she felt like she had finally shaken off the darkness and negativity that followed her for years.
Asked what she would call her next chapter after releasing her memoir, "This Is Me: A Reckoning," Hayden said she wasn't ready to name it ... but felt one door had closed and another had opened.
8/17/2026 6:32 AM PT -- TMZ has obtained photos of the emergency response that showed up to the scene.
8/17/2026 3:45 AM PT --Hayden Panettiere was found dead by a friend inside a South Carolina home ... Emergency Medical Service workers responded to a call that came in of a person in "cardiac arrest" and an "unresponsive female," TMZ has learned.
8:33PM PT -- Law enforcement sources confirm police responded to an incident involving Hayden Sunday and there is currently an open investigation.
8:20PM PT -- A source close to Hayden tells TMZ ... she recently had been complaining about back pain in the past year.
Hayden Panettiere, best known for her roles in "Heroes" and "Nashville," has died at 36, TMZ has learned.
Sources with direct knowledge tell TMZ ... Hayden passed away earlier on Sunday. We're told she and her on-again, off-again boyfriend Brian Hickerson flew from Los Angeles to the south on Saturday. Sources tell us Brian's family is aware.
"It is with profound sadness that we share the tragic passing of our beloved Hayden. She was an incredible light and a force of nature who brought immeasurable love and joy to all who knew her -- and to the millions who watched her onscreen," her rep said in a statement to ABC News.
Hayden became a household name as a child actress before landing her breakout role as cheerleader Claire Bennet on NBC's "Heroes." She later starred as country singer Juliette Barnes on "Nashville," earning multiple award nominations for her performance.
Hayden Panettiere's death sent shockwaves through Hollywood ... and several of her former co-stars are sharing their reactions ... and it's emotional.
Friends and fans flooded social media with messages, including several actors from the 'Scream' franchise -- Hayden's a fan favorite in the slasher flicks.
As we told you ... Hayden was found dead inside a South Carolina residence on Sunday ... and an emergency call was made for an "unresponsive female" in "cardiac arrest." Police say there were no initial signs of foul play and the circumstances surrounding Hayden's death did not appear to be suspicious.
