Christina Applegate Reveals MS Misdiagnosis 'I’ve Gotten Worse'

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After years of believing she was suffering from multiple sclerosis, Christina Applegate has now shockingly revealed that she doesn't have the disease.

The actress returned Tuesday to her podcast, "MeSsy," with cohost Jamie-Lynn Sigler after taking a sabbatical in March -- and she had some bombshell news to report to everyone.

In the first of 2 episodes, Christina announced that she learned from her doctor she did not have MS and, as a result, she needed to take some time off from her podcast to process the information.

Christina Applegate First Photos Since Lengthy Hospital Stint

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NEW 'DO, NEW DAY

Christina Applegate appears to be on the mend after returning home from a long hospital stay. 

The "Married with Children" actress posted a short video of herself showing off a new hairdo and looking good. 

Christina captioned the post ... "Fresh hair color, new weird spot on my cheek haha thank you @davestanwell for brightening up my cloudy day. Love you and love to you all out there."

Christina Applegate Discharged From Hospital After Lengthy Stay

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Christina Applegate is back home after a nearly four-month hospital stay ... TMZ has learned.

Sources with direct knowledge tell TMZ ... Christina, who had been hospitalized in Los Angeles since late March, was recently discharged.

A source close to the actress tells us she is home and doing well.

We broke the story ... the actress was hospitalized in early spring, though it was unclear at the time why she was admitted or how long she would remain there.

Christina Applegate 'Stronger and Better' After Hospitalization

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Christina Applegate gave her fans a fright last week when it was revealed she'd been in the hospital.

TMZ broke the story ... the actress was admitted to an L.A. hospital late last month, but it's unclear why or how long she was there.

On Monday, she took to Instagram to reassure fans she's OK and thank them for the "outpouring of love and well wishes."

Christina Applegate Hospitalized Amid MS Battle

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Christina Applegate is currently hospitalized in Los Angeles ... TMZ has learned.

Sources with direct knowledge tell TMZ ... she was admitted in late March, though the exact reason for her stay remains unclear.

The actress has battled multiple sclerosis since first being diagnosed in June 2021, but it's unclear if her hospitalization is related to the disease.

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TAKIN' A BREAK
MeSsy with Christina Applegate & Jamie-Lynn Sigler

This follows a March 31 announcement from Applegate's MeSsy podcast co-host, Jamie-Lynn Sigler, that the show would go on a brief hiatus while both hosts were on book tours. Sigler has lived with relapsing MS for more than 20 years.

Christina Applegate Hospitalized 30 Times Due to Diarrhea, Vomiting ... In Ongoing MS Battle

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Christina Applegate says she's been hospitalized "upwards of 30 times" from throwing up, diarrhea, and excruciating pain ... and she thinks it stems from her MS.

The "Married... with Children" star -- who was diagnosed with multiple sclerosis in 2021 -- opened up about her rather crappy experiences on her latest 'MeSsy' podcast episode as she and her cohost Jamie-Lynn Sigler addressed a note from a listener also battling the autoimmune disease and dealing with frequent diarrhea and vomiting.

During the candid discussion, CA admits when she needs to go No. 2, she oftentimes also pukes ... and is certain there's a correlation between her upset stomach and MS, despite doctors not being totally convinced.

CHRISTINA APPLEGATE TALKS DEPRESSION BATTLE OVER MS ... 'Trapped in Darkness'

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Trapped In Darkness

Christina Applegate's always been open about her MS struggles ... and now she's also revealing her battle with deep depression, which has left her with no joy in living.

On the latest 'MeSsy' podcast episode, Christina told her buddy Jamie-Lynn Sigler her current bout of depression -- which hit after her 2021 multiple sclerosis diagnosis -- is so intense it's something she hasn't experienced in years.

Hear it out in her own words ... she describes it "like a real, f*** it all depression where it's kind of scaring me too a little bit because it feels really fatalistic. I'm trapped in like this darkness right now that I haven't felt like ... I don't even know how long, probably 20-something years."

CHRISTINA APPLEGATE WEARING DIAPERS AFTER STOMACH BUG 'Pissing Out Of My A**!!!'

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DIAPER EMERGENCY
MeSsy with Christina Applegate & Jamie-Lynn Sigler

Christina Applegate once had a stomach bug that was so intense that it forced her to start wearing diapers ... something she says she still does to this day, out of precaution.

The actress went into graphic detail about this on a new episode of her podcast ... telling co-host Jamie-Lynn Sigler she resorted to wearing diapers due to her intense sapovirus battle -- which she chalked up to eating a tainted salad from a restaurant she frequented often.

Unclear when exactly this happened -- but CA says things were so bad that she started to feel dizzy and sick for 3 weeks, to the point where she couldn't eat or do much else.

Christina Applegate MS Pain, Brain Lesions So Bad Now ... It's Hard to Get Outta Bed

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IT'S A B****

Christina Applegate is giving us a window into her daily battles with multiple sclerosis ... which she says has become almost unbearably painful.

The actress -- who first shared her MS diagnosis in 2021 -- revealed on Dax Shepard's "Armchair Expert" podcast that she now has 30 lesions on her brain, the largest of which is behind her right eye. She says it's causing so much pain, she describes it as "the worst thing that's ever happened to me in my entire life. I hate it so much, and I'm so mad about it."

Thankfully, the lesion has yet to impact her vision. She has felt other MS side effects, however, as her mobility's been greatly affected.

Christina Applegate Standing Ovation At Emmys ... Jokes About Shaming MS

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"Don't shame me"

Christina Applegate got folks out of their seats at the Emmys ... and it's all because of her courage.

The "Dead to Me" star, who is dealing with her multiple sclerosis diagnosis, came out to a standing ovation as she presented the award for Outstanding Supporting Actress in a Comedy Series.

Christina used a cane to get to the stage as the crowd rose to its feet and applauded.

Ya gotta see the video ... she got emotional about the reception she was getting, and cracked a joke, saying ... "You're totally shaming me with disability by standing up."

Remember, Christina revealed her multiple sclerosis diagnosis back in 2021, referring to it as a "strange journey."

It's great to see her involved at the Emmys ... when she was up for a SAG award last year she said it would likely be her last award show as an actress because of MS.

At that award show she used a cane with a powerful message on it ... "F U MS." While her cane Monday night wasn't fitted with any such note, Christina's presence onstage said plenty.

If her acting career is over, as Christina's predicted, she could certainly still do award show presenting --- she had the Emmys crowd wrapped around her finger.

We covered it all on the latest episode of The TMZ Podcast, available on all podcast platforms.

Christina Applegate 'FU MS' Cane Front and Center At SAG Awards

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Christina Applegate was a standout at the SAG Awards Sunday ... not because of her nomination --- but because of her courage.

The awesome actress -- if you have any doubts, watch "Dead to Me" -- is dealing with her multiple sclerosis diagnosis, and showed up with a cane with a powerful message.

As she entered the Fairmont Century Plaza in Century City, CA with her 12-year-old daughter Sadie, she was clutching a cane with the initials, "FU MS."

Christina was up for Outstanding Performance by a Female Actor in a Comedy Series ... she said earlier this month it likely would be "my last awards show as an actor probably, so it's kind of a big deal."

As we reported, Christina revealed her multiple sclerosis diagnosis back in 2021 ... calling it a "strange journey," but one she's on with the support of others that share her condition.

She also dragged the disease late last year when she got her star on the Hollywood Walk of Fame -- flashing her painted nails with "FU MS" emblazoned on them.

Unfortunately, Christina didn't take home gold at the SAG Awards, but the outpouring of support she's been receiving has been heartwarming.

BTW ... if you haven't seen "Dead to Me," you're missing an incredible performance.

Christina Applegate I Gained 40 Pounds & Walk With Cane ... As A Result Of MS

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Christina Applegate is opening up about her struggles with multiple sclerosis, ahead of her first appearance on the big screen ... revealing she put on 40 pounds and can't walk without a cane.

The "Married... with Children" star got candid with the New York Times ... saying the upcoming season of "Dead to Me" would be "the first time anyone’s going to see me the way I am."

Christina said she had been struggling to accept the weight gain and her impaired mobility ... saying she's aware of all the changes but says, "I'm never going to accept this."

She took it a step further, saying she felt she had to "process the loss of [her] life" ... and was forced to accept a new normal.

As we reported, the actress revealed she'd been diagnosed with MS back in August, 2021. At the time she said, "It's been a strange journey. But, I have been so supported by people that I know who also have this condition."

She continued, "It's been a tough road. But, as we all know, the road keeps going. Unless some asshole blocks it."

The "Dead to Me" series is returning to Netflix November 17.

Christina Applegate I Have Multiple Sclerosis

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Christina Applegate is sharing devastating news ... she has multiple sclerosis.

The actress revealed the news Monday night saying, "A few months ago I was diagnosed with MS. It's been a strange journey. But I have been so supported by people that I know who also have this condition."

The "Married... with Children" star added, "It’s been a tough road. But as we all know, the road keeps going. Unless some asshole blocks it." In a separate tweet, Christina said she has a friend who has MS ... for which there is no cure. The autoimmune disease starts with the body's immune system attacking its own tissues.

Selma Blair, who also has MS, told us back in 2019 how she's adapted to life since the diagnosis. She continued acting and was a huge inspiration to others. Some of her treatments included chemo and a stem cell transplant.

It's not the first time Christina's battling a medical scare. The "Bad Moms" star, at just 36 years old, was diagnosed with breast cancer in 2008 and she made the decision to have a double mastectomy. Christina's mom, Nancy Priddy, is also a breast cancer survivor.